However, these studies primarily focused on clustering and differential analyses but did not fully exploit the single-cell sequencing data to explore, for example, pseudo-temporal dynamics.
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Indeed, recent single-cell sequencing studies of aged and AD brains revealed a series of brain cell clusters involved in AD. Understanding the cell-type-specific changes and regulations at the single-cell level will enable us to decode the molecular mechanisms underlying the pathophysiologic processes contributing to dementia. Further, the recently discovered five molecular subtypes of AD were associated with unique molecular signatures and distinct sets of brain cell type-specific key regulators. Postmortem evaluations revealed that AD brains may include depositions of additional pathologies (i.e., beyond Aβ and phosphorylated tau), such as Lewy bodies, alpha-synuclein, transactive response DNA-binding protein and/or vascular-related brain lesions.
While AD often progresses through a period of mild cognitive impairment (MCI), not all patients with MCI develop AD, hinting at protective or causal factors that may differentially affect subsets of patients even within traditional subtypes. AD can be classified by heritable cause and age of onset, i.e., rare familial AD, sporadic early-onset (EOAD), and late-onset (LOAD). ĪD is a highly complex and heterogeneous disease caused by various pathophysiologic mechanisms. A more definitive AD diagnosis requires evidence of amyloid-beta (Aβ) plaques and Tau neurofibrillary tangle (NFT) accumulation within the neurodegenerative brain. Clinically, AD patients present amnestic multidomain progressive dementia. Co.Įncompass Property And Casualty Insurance CompanyĪmerican Alternative Insurance CorporationĪttn: Consumer Services Fl 25 S CNA PlazaĬarol Fuller, CPCU, Supervisor Reg.Alzheimer’s disease (AD) is one of the most devastating forms of dementia common in the elderly, estimated to affect over 6.2 million individuals in the United States and 24 million worldwide. Old Republic General Insurance CorporationĬustomer Relations Department C1-36 Hartford Plaza Travelers Casualty Company Of Connecticut Stillwater Property and Casualty Insurance CompanyĪmerican Guarantee And Liability Insurance CompanyĪmerican Family Connect Property and Casualty Insurance Company Great American Alliance Insurance CompanyĬall Center/Allstate Claims AdministrationĪmerican Casualty Company Of Reading PennsylvaniaĪttn: Consumer Services, Floor 25 South, CNA Plaza Travelers Property Casualty Insurance CompanyĪce Property And Casualty Insurance CompanyĮncompass Home And Auto Insurance Company
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